The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

The 49ers were coming off a Super Bowl appearance and the Bills had all the look of a team that would regress. But the season hasn't really gone the way people predicted for either team. This week, Buffalo hopes to clinch a fifth-straight AFC East title,

Two words can sum up the Week 12 matchup between the visiting San Francisco 49ers and the host Green Bay Packers: utter domination. The Packers cruised to a 38-10 victory, marking the franchise's largest win against the 49ers ever,

The 49ers just lost 38-10 to the Green Bay Packers. Here are the 49ers' grades for this performance. QUARTERBACK: C-MINUS. Brandon Allen was decent considering he had

The Green Bay Packers produced a dominant win over the San Francisco 49ers on Sunday at Lambeau Field, using a powerful performance from Josh Jacobs in the run game and a disruption-filled game from the defense to win 38-10.