In this webinar, Robert Lowrey and David Siderovski will discuss novel AI-driven drug discovery approaches targeting difficult proteins.

High-throughput screening (HTS) is crucial to generate hits and leads in drug discovery efforts. Most high-throughput biochemical assays are based on optical detection or radioactivity with high ...

In drug development projects, evaluating drug-target residence times can enhance drug efficacy, widen the therapeutic window, and reduce the likelihood of prematurely advancing candidate compounds ...

Traditional 2D monolayer cell cultures often fail to accuratelyreplicate the complex cellular microenvironment found in living organisms. In contrast, 3D cell-based assays allow cells to grow into ...

Whether They Are Used In Drug Screens or Precision Medicine, Cell-Based Assays Are All About Context Cells are miniature laboratories that allow scientists to study key biological processes. As a ...

In this Interview, NewsMedical speaks with Amy Landreman about NanoBRET® Technology and its role in cellular target engagement. Could you start by explaining the significance of understanding cellular ...

Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most frequently mutated oncogene, present in approximately 25% of tumors. Numerous studies on KRAS in the initiation and advancement of ...

Researchers engaged in drug discovery and development seek strategies for understanding the dynamics of drug-target interactions. Measuring the drug-target residence time—the duration of time that a ...

Professor of Chemical and Biological Engineering, Biomedical Engineering, and Public Health, Colorado State University A vast number of chemicals are registered for production and use around the world ...

A photo illustration shows Weixue Wang surrounded by a protein structure and an assay. Credit: Will Ludwig/C&EN/Tim Peacock/Scorpion Therapeutics There's a thread running through Weixue Wang's ...