In a small clinical study, investigators from Marshall University School of Medicine found that the consumption of two ounces of walnuts per day for about two weeks significantly changed gene ...

Gene-expression profiling with the use of DNA microarrays allows measurement of thousands of messenger RNA (mRNA) transcripts in a single experiment. Results of such studies have confirmed that breast ...

To facilitate comparison of the labeling data with the histology, virtual slides were created from the stained breast tissue microarrays using an Aperio ScanScope (Aperio Technologies, Vista, CA, USA) ...

Gene expression testing helps determine chemotherapy needs for HR+ breast cancer, optimizing treatment and reducing unnecessary toxicity. Breast cancer treatment continues to evolve with advancements ...

Breast cancer is the most common cancer to affect women, with over 40 000 new cases being detected and around 13 000 women dying from the disease in Britain each year (CancerStats, 2005). The ...

bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group study. The level of TS expression was evaluated in 210 node-negative and 278 ...

Increasing oestrogen receptor (ER) level in breast cancer is associated with more favourable prognostic parameters and with improved survival, according to an analysis of the Nottingham cohort over a ...

Endocrine agents, such as letrozole, are established in the treatment of hormone-dependent breast cancer. However, response rates are only 50% to 70% in the neoadjuvant setting and lower in advanced ...

Using microarray analysis to evaluate our previously established 70-gene prognosis profile, we classified a series of 295 consecutive patients with primary breast carcinomas as having a ...

In a study using a mouse model of aging that mimics breast cancer development in estrogen receptor-positive post-menopausal women, investigators have determined that over-expression, or switching on ...