Cells have to invest a lot of energy to maintain this concentration gradient, especially when it comes to getting rid of calcium. 'It's like being on a rush-hour train in a city like Tokyo. When the ...

Our cells move energy and matter to the places it is needed. But how do they do this in real time, and seen from the perspective of a single molecule? Scientists have successfully uncovered new basic ...

High-speed pumps: Cells use high-speed pumps to pump calcium ions out of their interior. A team has created the first comprehensive transport model of plasma membrane CaATPase (PMCA) to study calcium ...

The plasma membrane calcium pumps (PMCAs) are vital ATP‐dependent transporters responsible for the expulsion of calcium ions (Ca2+) from eukaryotic cells, thereby maintaining the low resting ...

Biochemists have uncovered the structure of cellular mechanism tied to thought, movement and other bodily functions. New atomic scale images of the structure of calcium's gatekeeper, IP3R, could go a ...

The first high resolution structure of an ATP-dependent cation pump of the P-type family — the Ca 2+-ATPase from the sarcoplasmic reticulum of rabbit muscle — has now been determined. Figure 1: ...

The first comprehensive transport model of a plasma membrane calcium pump explains its high speed and opens up new avenues for drug development 'Drink your milk and you will have strong bones and ...