Foxglove plants, found in many gardens, are known for the showers of bell-shaped flowers they produce. But plants belonging to this genus, Digitalis, also harbor a less visible asset: chemicals called ...

The unfolded protein response (UPR) is a pivotal mechanism to mitigate protein homeostasis through transcriptional or translational control. On the other hand, since dysregulation of UPR has been ...

Digitalis has been used to treat heart failure for more than 200 years. The drug digitoxin also belongs to this group of active ingredients known as cardiac glycosides. Although there were indications ...

Foxglove plants, found in many gardens, are known for the showers of bell-shaped flowers they produce. But plants belonging to this genus, Digitalis, also harbor a less visible asset: Chemicals called ...

To understand better and more deeply appreciate the development of knowledge in this field, it is desirable to begin with the simpler aspects of the action of these glycosides and then to proceed to ...

MADRID -- Digitoxin added to guideline-directed medical therapy improved outcomes among patients with heart failure and reduced ejection fraction (HFrEF), the DIGIT-HF trial showed. The cardiac ...

Digitalis has been used to treat heart failure for more than 200 years. The drug digitoxin also belongs to this group of active ingredients known as cardiac glycosides. Non-antibiotic drugs can alter ...

The basic rule concerning the therapeutic dosage of the cardiac glycosides was delineated long ago by Withering, who wrote, "Let it be continued until it either acts on the kidneys, the stomach, the ...