DNA is not randomly distributed within the nucleus but is packaged with proteins into chromatin, which is precisely folded ...

As researchers unravel the machinery that controls gene expression, they are finding more mechanistically informed ways to intervene in disease.

Chromatin is a structure in the cell nucleus that helps pack DNA tightly by wrapping it around proteins called histones. These DNA-protein units, called nucleosomes, control how genes are turned on or ...

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact within these droplet-like structures. The findings connect molecular ...

Inside each human cell, about 2 meters (6.6 feet) of genomic DNA must be accurately copied and equally transmitted to two daughter cells during cell division. To achieve this, the copied DNA is ...

A research team led by professor Chan Kui-ming from the Department of Biomedical Sciences at CityUHK discovered that H2BE113K, a missense H2B mutation, promotes colony formation and lung metastasis in ...

Chromatin's structure plays an important regulatory role in DNA template-dependent processes including transcription, replication, recombination, repair, segregation, chromosomal stability, cell cycle ...

The way the body ages could be more resilient than previously thought, a new study suggests. Published in the Journal of the American Chemical Society, the work by researchers at King's College London ...