Self-DNA triggers cGAS-STING-mediated type I interferon (IFN-I) to induce both protective and pathogenic immune responses; however, how self-DNA activates the cytosolic cGAS-STING pathway remains ...
Fluorescence microscopy illustrates immune cell–mediated extraction of nuclear DNA from dying cells, highlighting a newly identified process called nucleocytosis. Over the years, cell biology has ...
Efficient extraction of circulating cell-free DNA (cfDNA) from plasma is critical for liquid biopsy applications, but remains challenging due to cfDNA’s short fragment size, low concentration, and the ...
Similar to the way DNA damage can contribute to human diseases such as cancer, it can also disrupt growth, development and ...
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