ALZFORUM

γ-Secretase Cuts Not Just Notch, but Ligands Delta and Jagged, Too

A report in the January 24 online Journal of Biological Chemistry indicates that the Notch ligands Delta and Jagged are also substrates for γ-secretase, the intramembrane aspartyl protease responsible ...
JSTOR Daily

Delta/Notch signaling in glia maintains motor nerve barrier function and synaptic transmission by controlling matrix metalloproteinase expression

While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling ...
Nature

d-Asb11 is an essential mediator of canonical Delta–Notch signalling

The alternative text for this image may have been generated using AI. Figure 5: Activation of Notch reporters by d-Asb11 requires other cells (a) When d-Asb11 was overexpressed in the same cell as the ...
Science Daily

Scientists uncover a new role for blood-brain barrier in neuron function and damage

Researchers have made a surprising discovery linking Delta/Notch signaling in subperineurial glia (SPG) to the regulation of nerve ensheathment and neurotransmitter release at the Drosophila ...
Nature

DNER acts as a neuron-specific Notch ligand during Bergmann glial development

Differentiation of CNS glia is regulated by Notch signaling through neuron-glia interaction. Here, we identified Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, ...