An MRI-based cohort study shows HLA-B27–positive axial spondyloarthritis is linked to higher inflammation and distinct ...

This study involved 40 patients who met 3 criteria: HLA (human leukocyte antigen)-B27 positivity; less than 3 years of back pain that on history seemed inflammatory; and magnetic resonance imaging ...

Sacroiliitis (SI) is reported to develop in up to 20% of patients with inflammatory bowel disease (IBD). While sex and the HLA-B27 allele have been reported to be associated with sacroiliitis in the ...

Axial spondyloarthritis (axSpA) is a type of inflammatory arthritis that affects the spinal joints and the joints that connect the bottom of the spine to the hip bones (the sacroiliac joints). Experts ...

In patients with spondyloarthritis, onset of common musculoskeletal symptoms such as back pain led to diagnostic delays averaging over 7 years. Onset with extra-musculoskeletal manifestations such as ...

Ixekizumab reduced erosion and increased backfill in the sacroiliac joints of biologic disease-modifying antirheumatic drug (bDMARD)–naive patients with radiographic axial spondyloarthritis (r-axSpA) ...

The etiopathogenesis of ankylosing spondylitis (AS) is not fully understood. However, there is strong evidence indicating that genetic factors play a pivotal role in disease susceptibility, and that ...