Study establishes for the first time that defective DNA repair may be the major driver of several clinical features associated with a subset of patients with 22q11.2 distal deletion syndrome ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

Validation of a 15-Gene Prognostic Signature in Metastatic Clear Cell Renal Cell Carcinoma Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ...

Kelim index as predictor of treatment outcome in ovarian cancer surgery. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text component.

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the mechanism by which cells identify and repair a highly toxic form of DNA ...

Ultraviolet (UV) radiation is known to cause DNA damage, and while that damage may accumulate and eventually lead to diseases like skin cancer, cells also have repair mechanisms that can fix ...

Artios Pharma collected $115 million from an oversubscribed series D that will support its growing ambitions for its pipeline of DNA damage response (DDR)-targeting cancer prospects. The biotech is ...