Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation ...
Discovered in the 1990s, the JNK protein, or, to give it its full name, c-Jun NH 2-terminal kinase, was found to be the protein kinase responsible for the phosphorylation of c-Jun at Ser-63 and Ser-73 ...
Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs) have important roles in the signalling mechanisms that orchestrate cellular responses to many types of stresses, but ...
Molecular pathways that influence cellular life-and-death decisions increasingly fall under the scientific spotlight. In 1996, researchers discovered that NF-kB is anti-apoptotic, which led to the ...
Morphologic and genomic characterization of circulating tumor cells in patients with metastatic colorectal cancer treated with combinational treatment of andecaliximab, bevacizumab and chemotherapy.
Relationship of the oncogene Notch and CXCR4/SDF1 signaling in human epithelial ovarian cancer.
Jun NH₂-terminal kinases (JNKs) regulate convergent extension movements in Xenopus embryos through the noncanonical Wnt/ planar cell polarity pathway. In addition, there is a high level of maternal ...
A study led by Garvan researchers has uncovered why some breast cancers become resistant to treatment, potentially opening the door to more effective therapies for patients. Published today in the ...
Janus kinase (JNK) inhibitors with antiviral and anti-inflammatory properties have shown promising outcomes in treating symptomatic coronavirus disease 2019 (COVID-19) patients. In a systematic review ...
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