BETHESDA, Md., Thurs., Sept. 7, 2006 – The National Institutes of Health (NIH) today awarded a set of cooperative agreements, totaling up to $52 million over five years, to launch the Knockout Mouse ...

In recent debate over the FDA's approval of the Alzheimer's drug aducanumab, we've heard a lot about the "amyloid hypothesis." In that context, it's refreshing to learn about a model of Alzheimer's ...

Scientific evidence suggests that not only murine scent communication is regulated by major urinary proteins, but that their expression may also vary in response to metabolism via a yet unknown ...

We describe a system for introducing guide RNAs (gRNAs) to Cas9-expressing hematopoietic stem cells, which are used to generate mice with gene knockouts in the immune system. By using different ...

Super immunodeficient mouse models with knockout of murine Fc gamma receptors (FcγRs) have emerged as valuable tools in biomedical research for improving the accuracy of preclinical experimental ...

In the context of recent debate over the FDA's approval of aducanumab, it's refreshing to learn about a model of Alzheimer's neurodegeneration that doesn't start with the pathogenic proteins amyloid ...

GluN3A-deficient mice display all aspects of Alzheimer's neurodegeneration. In the context of recent debate over the FDA's approval of aducanumab, it's refreshing to learn about a model of Alzheimer's ...