The research team developed a genetically engineered mouse model carrying a mutation (E3896A) in RyR1, which disrupts its calcium-binding site, effectively disabling CICR while preserving ...

Intracellular Ca 2+ is pivotal in various aspects of cell physiology, including neuronal transmission, apoptosis, gene transcription, and cell migration 1,2. The essential role of Ca 2+ is underscored ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...

The occurrence of diseases characterized by irregular spinal alignment, such as kyphosis, lordosis, scoliosis, and dropped head syndrome (DHS) is increasing, particularly among older adults. DHS is ...