Nearly 98% of the human genome does not encode proteins but comprises noncoding sequences—the “dark genome”—such as regulatory sequences that control gene transcription (enhancer elements). Thousands ...

In the vast majority of diseases caused by mutations in a single DNA sequence, the disruption of a gene is to blame. However, many non-coding elements in the genome, which inhabit what is sometimes ...

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called ...

Researchers at the Centre for Genomic Regulation (CRG) have identified a DNA sequence that is crucial for pancreatic differentiation and function – and for the first time – describe how it works.

Animal diversity and evolution are driven by changes in how our genetic code is expressed. Specific DNA sequences called enhancers control where, when and how strongly genes are expressed during ...

In a study published in Genome Research, a team of researchers, including Cornell College Assistant Professor of Biology Sophie Gillett, looked at regions of human genetic code that are known for ...

Genetic mutations can increase a person’s cancer risk, but other gene “enhancer” elements may also be responsible for disease progression, according to new research out of Case Western Reserve ...

Researchers at the Centre for Genomic Regulation (CRG) have identified a DNA sequence that is crucial for pancreatic differentiation and function – and for the first time – describe how it works.