A protein has been identified that promotes the formation of osteoclasts, bone-degrading cells—while also inhibiting osteoblasts, bone-forming cells. The findings could lead to new avenues of drug ...

Osteoclasts are specialized, multinucleated cells that play a vital role in bone development and regeneration. Credit: vetpathologist/Shutterstock.com The skeleton is ...

Bone is a connective tissue that serves important mechanical and metabolic functions. It provides mechanical support for locomotion, protects vital organs such as the bone marrow and brain, serves as ...

The review of more than 60 scientific articles showed that microplastics, among other effects, can stimulate the formation of osteoclasts, cells specialized in degrading bone tissue. Microplastics ...

INTRODUCTION Calcific aortic valve disease is associated with inflammation and calcification, thus the osteoprotegerin (OPG), receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) ...

Nobuyuki Udagawa, Naoyuki Takahashi, Takuhiko Akatsu, Hirofumi Tanaka, Takahisa Sasaki, Tatsuji Nishihara, Toshihiko Koga, T. John Martin and Tatsuo Suda Proceedings of the National Academy of ...

As part of our natural bone development, special cells on the surface break down old bone tissue and then build it back up again. When changes occur to this cycle and throw things off balance, ...

The skeleton undergoes continuous remodeling throughout life in response to diverse environmental stimuli. Osteoclasts, which are specialized cells on the bone surface, break down old bone tissue (in ...

Bone may seem as if it’s a hard, lifeless structure, but now the cells living within have been imaged in unprecedented detail, thanks to an innovative imaging method developed at the Garvan Institute ...

Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

Bisphosphonates decrease bone resorption and are commonly used to treat or prevent osteoporosis. However, the effect of bisphosphonates on their target cells remains enigmatic, since in patients ...