Indianapolis, IN - The latest effort to deploy phospholipase A2 (PLA2) inhibitors as anti-inflammatory agents in rheumatoid arthritis (RA) crashed and burned this month when Lilly Research ...

A total of 65 colorectal carcinomas were studied. In all, 17 carcinomas had a totally ulcerated or necrotic surface; thus 48 samples could be evaluated with regard to cytoplasmic PLA2 and COX-2 ...

Immunotherapy. 2013;5(4):315-317. The Ca-independent PLA 2 s (Group VIA-F) do not show any preference for fatty acid at the sn2 site and are considered to be mainly involved in membrane ...

A new study from Yale University School of Medicine found that inhibition of cytosolic phospholipase A2 (cPLA2), which drives inflammation and chondrocyte aging, preserves cartilage and reduces pain.

Image Caption: Pyruvate inhibits TNFα/NF-κB signaling and the expression of downstream pro-inflammatory genes. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles ...