The study is published in the journal National Science Review. The long-overlooked structural feature of the rotary carbonyl rings underpins the ultra-high K + /Na + selectivity, but has never been ...

Voltage gated potassium (Kv) channels regulate processes from cellular excitability to immune response and are major pharmaceutical targets. Despite recent structural advances, the closed state ...

The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block ...

Potassium channels are openings that allow charged potassium atoms to cross the cell membrane. Voltage-gated potassium channels — which open only when a specific voltage is reached across the cell ...

Researchers have discovered a new mechanism for potassium channel inhibitor entry, which could improve the specificity of drugs targeting the channel. Upon binding to calcium ions, BK channels allow ...

Potassium channels are openings that allow charged potassium atoms to cross the cell membrane. Voltage-gated potassium channels—which open only when a specific voltage is reached across the cell ...

Intrigued by the properties of ion channel proteins commonly observed in cells, researchers have developed the first synthetic mechanosensitive potassium channel using a newly developed aromatic ...

Underlying every thought, heartbeat and movement are ion channels, busily conducting high-speed streams of ions into cells, like subway trains coursing through tunnels. Ion channels span the cellular ...

Following this design principle, the researchers create angstrom-scale pores in bi-layer graphene sheets, and decorate the two pore edges with twisted rings of carbonyl groups. The artificial ion ...