Chung’s group captured the transition period directly by improving the time resolution of a method called single-molecule ...

High-resolution structures of nascent polypeptide chains in complex with the ribosome — the cell’s protein-synthesis machinery — reveal how the ribosome guides protein folding. Ribosomal attachment ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

The strategies biopharmaceutical manufacturers currently use to limit protein misfolding are complex, time-consuming, and generate low yields with only limited scalability. Covalent organic frameworks ...

For those outside the chemistry cognoscenti, the announcement might have seemed little more than researchers patting each other on the back. But the question of protein folding had plagued scientists ...

The latest short science news items from C&EN. Proteins are vital for life, involved in virtually every biochemical process that makes life possible. They comprise one or more amino acid chains ...

In order to fulfil their many functions, proteins must be folded into the correct shape. Researchers at the University of Basel have now discovered tiny “folding factories” in cells that enable ...

Proteins are the molecular machines of cells. They are produced in protein factories called ribosomes based on their blueprint—the genetic information. Here, the basic building blocks of proteins, ...

Artificial intelligence (AI) is reshaping the scientific landscape, offering fantastic solutions to some of the most pressing global challenges. From combating climate change to transforming ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...