Members of the phylum Bacteroidota utilize the type IX secretion system (T9SS) to transport diverse substrates into the environment or onto their surface. T9SS substrates feature a Sec-dependent ...

Bacteroidetes species employ specialised secretion systems to deliver a wide array of effector proteins that underpin colonisation, nutrient acquisition and host interaction. Central to pathogenic ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

A group of international researchers reports the availability of a new “map”’ of every gene, protein, and metabolic pathway required for a cell to efficiently secrete recombinant proteins. The team, ...

Researchers developed a “test tube” so tiny that it can hold a single cell. These vials enabled them to connect protein secretion levels with surface markers and transcriptome data from the same cell.

snoRNAs were thought simply to guide chemical modifications to rRNAs, but a new technique has revealed a suite of potential functions in protein secretion. A recent research effort from the University ...

Cells have sophisticated methods of sensing stimuli and communicating with nearby cells in response to these stimuli. For example, macrophages can sense environmental stimuli—tissue damage, foreign ...

Uncontrolled secretion of extracellular matrix (ECM) proteins such as collagen can lead to excessive scarring and fibrosis, and compromise tissue function. Researchers at the Center for Genomic ...

In type 2 diabetes, the body's ability to release insulin is impaired, which leads to high blood glucose levels. Research led by Lund University shows how the levels of a particular protein are ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...