In drug discovery, researchers think a lot about how tightly a small molecule binds to its target. For a long time, drug developers have considered tightly binding compounds better, more promising ...
When a drug molecule binds to its target protein, it stays bound for some time before eventually unbinding the target. The actual time how long a drug molecule resides bound to its target varies among ...
A new study helps to explain what defines how long a drug molecule stays bound to its target. A new study from the University of Eastern Finland and the University of Tübingen helps to explain what ...
DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation
Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27 to mark genes for repression. We measured the dynamics of PRC2 binding on recombinant chromatin and free DNA at the ...
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