When neuroscientists analyzed the exact properties of nerve connections in the brain, they made a startling observation: At a key connection, or synapse, messages are sent against the usual stream of ...

BIN1, one of the strongest genetic risk factors for late-onset Alzheimer’s disease, encodes a protein that dabbles in many cellular functions, taking a hand in Aβ production, tau propagation, and ...

This is a preview. Log in through your library . Abstract Hyperpolarization-activated nonselective cation channels (Ih channels) play an important role in the control of membrane excitability and ...

Physiological functioning and homeostasis of the brain rely on finely tuned synaptic transmission, which involves nanoscale alignment between presynaptic neurotransmitter-release machinery and ...

The authors have performed a potentially valuable new kind of analysis in connectomics, mapping to an interesting developmental problem of synaptic input to sensory neurons. While the analysis itself ...

Synaptic transmission tenets challenged Two distinct pools of synaptic vesicles appear to be involved in the spontaneous release of neurotransmitters and in neurotransmission triggered by a stimulus, ...

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, ...

This study is led by Prof. Jun Li (Peking University Sixth hospital), Prof. Dai Zhang (Peking University Sixth hospital), Dr. Yuanlin Ma (Peking University Sixth hospital; The First Affiliated ...

(1) A nerve impulse arrives. (2) This causes calcium ion channels to open, resulting in an influx of calcium ions in the terminal. (3) This causes synaptic vesicles to fuse with the terminal membrane, ...

A recent multi-species study has found that the CD2AP gene, a known risk gene for Alzheimer’s disease, is key for regulating synaptic transmission. A multi-species study integrating experiments in ...