Thoracic aortic dissection is often approached as an acute and localised event, and pathological examination has ...

Researchers have discovered a genetic mutation that can cause dissection of the thoracic aorta, which is the body’s main artery. The mutation leads to an impaired function of the smooth muscle cells ...

Through genetic analysis of a family with a history of thoracic aortic aneurysm and dissection (TAAD), investigators have identified mutations in the LOX gene, a gene associated with the integrity of ...

Another particular vascular syndrome that associates TAA/AD and patent ductus arteriosus (PDA) has been suggested in a single family. 13 We report here the study of a large three-generation French ...

Patients who have an error in the gene known as LOX—shorthand for lysyl oxidase, the enzyme it encodes—are particularly prone to thoracic aortic aneurysm and ...

An aortic dissection which occurs when a tear in the inner wall of the aorta causes blood to flow between the layers of the wall of the aorta and force the layers apart. This transthoracic ...

In patients with ascending thoracic aortic aneurysm (TAA) and no other organ-system abnormalities, the absolute risk of aortic dissection is low but increases with larger aortic sizes, according to ...

The pathogenesis of sporadic thoracic aortic aneurysm and dissection, which may lead to rupture of the aorta, remains largely unknown. Amyloid deposits, formed from the medin peptide, are very ...