Nature

Impact of trisomy 8 on treatment response and survival of patients with chronic myelogenous leukemia in the era of tyrosine kinase inhibitors

A total of 610 (30%) patients had ACAs in addition to t(9;22)(q34;q11.2)/BCR-ABL. Of note, cases with chromosomal changes in Ph-negative cells were not considered as ACAs. Of 610 cases with ACAs, 183 ...
MedPage Today

In AML, How do Trisomy 8 and Measurable Residual Disease Affect Outcomes After HSCT?

—According to researchers in Germany, the presence of additional cytogenetic or molecular markers included in current risk stratification systems, rather than the presence or absence of a trisomy 8, ...
ascopubs.org

The role of FLT3 in sole trisomy 8 acute myeloid leukemia.

Hypocellular acute myeloid leukemia: Better or worse prognosis. Background: FLT3 (fms-related tyrosine kinase 3) with internal tandem duplication (ITD) is a known adverse prognostic factor in normal ...
Nature

High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration

Although trisomy 8 as the sole chromosome aberration is the most common numerical abnormality in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), little is known about its ...
ascopubs.org

Prognostic impact of trisomy 8 cytogenetic abnormality in acute myelogenous leukemia: Analysis of a large cohort (N=2187) of newly diagnosed patients.

Predictive factors associated with achievement of major cytogenetic response (MCyR) to omacetaxine mepesuccinate among patients with chronic phase chronic myeloid leukemia (CML-CP). Incidence and ...