eLife1d
A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus
This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...
eLife2d
Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
This interesting study presents valuable information on how human cytomegalovirus (HCMV) infection disrupts the activity of the TEAD1 transcription factor, leading to widespread chromatin alterations.
eLife2d
Evaluating hippocampal replay without a ground truth
During rest and sleep, memory traces replay in the brain. The dialogue between brain regions during replay is thought to stabilize labile memory traces for long-term storage. However, because replay ...
eLife2d
Still waters run deep: Large scale genome rearrangements in the evolution of morphologically conservative Polyplacophora
This compelling study is a splendid advance in approximately doubling the number of sequenced chiton genomes, providing what appears to be among the best genome annotations for chiton genomes ...
eLife2d
Magnetically Steered Cell Therapy For Functional Restoration Of Intraocular Pressure Control In Open-Angle Glaucoma
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, United States ...
eLife3d
Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria
This useful study presents findings on how some antibiotics, which inhibit protein synthesis in bacteria, affect the translation in mitochondrial ribosomes. The authors provide solid evidence that ...
eLife2d
Brain Activity: Unifying networks of a rhythm
Combining electrophysiological, anatomical and functional brain maps reveals networks of beta neural activity that align with dopamine uptake.
eLife5d
Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC
Department of Molecular Biology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka, Japan ...
eLife5d
GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine
Kokumi refers to the enhanced and more delicious state of food flavor. However, the underlying neuroscientific mechanisms remain largely unexplored. Our previous research demonstrated that ornithine ...
eLife3d
Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening
Nuclear condensates play many important roles in chromatin functions, but how cells regulate their nucleation and growth within the complex nuclear environment is not well understood. Here, we report ...
eLife3d
Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells
Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...
eLife5d
Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex
The prelimbic (PrL) cortex is vulnerable to insult from adolescent alcohol exposure and receives input from the basolateral amygdala (BLA) while sending projections to the ventrolateral periaqueductal ...