A new study shows p62-mediated Mallory-Denk body formation is an adaptive, protective response to alcohol-induced liver ...

Treatments that target a fragment of the mutant protein that causes Huntington's disease might be more effective than ...

Protein-based medicines are increasingly prevalent as a crucial category of contemporary therapeutics. The presence of ...

Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

Maryland Governor Hogan Visits Genesis Nursing Home as They Receive Their Covid-19 Vaccination on December 23, 2020. Source - Maryland GovPics. CC SA 2.0. Maryland Governor Hogan Visits Genesis ...

PRI-101 inhibited aggregation of α-synuclein and actively disassembled fibrils across in vitro and in vivo models relevant to Parkinson’s disease ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's. But to the human eye, proteins that are ...

Scientists at Northwestern, and Case Western Reserve universities have developed the first polymer-based therapeutic for the genetic disorder Huntington’s disease, an incurable neurodegenerative ...

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

The pathway leading to the telltale sign of ALS, protein aggregation in the cytoplasm of motor neurons, has been revealed. Researchers from the University of California – San Diego (CA, USA) have ...

Protein disaggregation is a critical cellular process wherein misfolded or aggregated proteins are solubilised and, in many cases, returned to their native configurations. Chaperone systems, including ...