Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

A new study shows p62-mediated Mallory-Denk body formation is an adaptive, protective response to alcohol-induced liver ...

Alcohol-associated liver disease (ALD) remains a leading cause of cirrhosis and liver-related mortality worldwide, with few effective therapies. In alcohol-associated hepatitis (AH), hepatocytes ...

Maryland Governor Hogan Visits Genesis Nursing Home as They Receive Their Covid-19 Vaccination on December 23, 2020. Source - Maryland GovPics. CC SA 2.0. Maryland Governor Hogan Visits Genesis ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's. But to the human eye, proteins that are ...

Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by the abnormal aggregation of pathological proteins ...

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

Scientists at Northwestern, and Case Western Reserve universities have developed the first polymer-based therapeutic for the genetic disorder Huntington’s disease, an incurable neurodegenerative ...

The pathway leading to the telltale sign of ALS, protein aggregation in the cytoplasm of motor neurons, has been revealed. Researchers from the University of California – San Diego (CA, USA) have ...

Protein disaggregation is a critical cellular process wherein misfolded or aggregated proteins are solubilised and, in many cases, returned to their native configurations. Chaperone systems, including ...