Watch the best plays from San Francisco 49ers quarterback Brock Purdy's 303-yard, five-touchdown game against the Chicago ...

The Seahawks held the 49ers to only 173 yards and three points to win the NFC West and secure home-field advantage throughout ...

With 7:14 to go in the opening quarter, Colts returner Ameer Abdullah received the kickoff and cut inside as Niners safety Ji ...

The San Francisco 49ers host the Seattle Seahawks at 8 p.m. ET (5 p.m. PT) Saturday at Levi's Stadium in Santa Clara, ...

It’s nearly Christmas and the 49ers have yet to punt in the month of December — and they may have to keep that up to claim the NFC’s top spot.

San Francisco's offense had been nearly unstoppable heading into a showdown with Seattle with the No. 1 seed in the NFC at ...

San Francisco 49ers quarterback Brock Purdy moves up to No. 7 in the team's list of passing touchdown leaders.

Purdy's career night kept the 49ers in the hunt for the NFC's top seed and dampened the Colts' already faint playoff hopes.

Brock Purdy threw a career-high five touchdown passes, two to running back Christian McCaffrey, and the San Francisco 49ers ...