Downstream bioprocessing steps have long been a challenge to drug manufacturers, particularly the chromatography step for purification of monoclonal antibodies (mAbs). The complexity of traditional ...

Process characterization and viral clearance validation are pivotal studies in biopharmaceutical manufacturing, particularly for monoclonal antibodies (mAbs) produced in mammalian systems, which carry ...

Purification by affinity chromatography on immobilized calmodulin is suitable for recombinant proteins expressed in bacteria because endogenous bacterial calmodulin-binding proteins are unknown.

Development of robust purification processes requires significant time and resources. In addition, steadily increasing demands from regulatory authorities for better understanding and control of ...

Detergents are indispensable as agents that can be used to disintegrate the structure of biological membranes with the object of purifying and characterizing their membrane protein components.

What is 2D liquid chromatography? Two-dimensional (2D) liquid chromatography is a powerful tool to separate complex compound mixtures. The principle behind 2D liquid chromatography is that compounds ...