Isaac Guerendo became the team's starter last week and the rookie scored two touchdowns against the Bears, but his day ended ...

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

The Los Angeles Rams will take on the San Francisco 49ers in Week 15 of the NFL season on Thursday. This prediction is based ...

The 49ers host the Rams on Thursday Night Football. They’ve been losing running backs left and right, and now we’re awaiting ...

Niners running back Isaac Guerendo, who is listed as questionable with a sprained foot, insists he "feels good" for ...

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the ...

The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The San Francisco 49ers host the Los Angeles Rams for Thursday Night Football but they may be without their standout rookie ...