San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the ...

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers’ season finale versus the Arizona ...

San Francisco running back Isaac Guerendo exited the 49ers' season finale versus the Arizona Cardinals just four plays into ...

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

It’s finally over. The San Francisco 49ers lost to the Arizona Cardinals on Sunday to put a stamp on what was one of the ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

San Francisco 49ers Isaac Guerendo was carted off the field Sunday against the Arizona Cardinals. He suffered the injury ...

The San Francisco 49ers entered Sunday's season finale against the Arizona Cardinals with a depleted roster. Quarterback Josh Dobbs took the reins in place ...

The 49ers lost another running back Sunday. Isaac Guerendo was carted off the field with injuries to his left knee and ankle. The team ruled out his ...

San Francisco 49ers head coach Kyle Shanahan recapped the team's 47-24 loss to the Arizona Cardinals and evaluated the 49ers overall performance in Week 18.

San Francisco 49ers QB Joshua Dobbs and LB Fred Warner reacted to the 49ers season finale against the Arizona Cardinals.