The Athletic has live coverage of Rounds 4-7 of the 2025 NFL Draft. Read more of The Athletic’s coverage from the 2025 NFL Draft: Best Players Available | Rounds 2 & 3 Grades | Day 2 Winners & Losers The San Francisco 49ers entered the 2025 NFL Draft with 11 total picks over the three-day draft.

SANTA CLARA, Calif. -- The three-day 2025 NFL draft began in Green Bay, Wisconsin, on Thursday. The San Francisco 49ers selected edge Mykel Williams with their first pick. Here's analysis of each pick the 49ers make:

"Delayed but significant injury news," Schefter wrote on X. "49ers safety Malik Mustapha, who was believed to be the replacement for free-agent safety loss Talanoa Hufanga, tore his ACL during San Francisco’s regular-season finale and is not expected to be ready for the start of the 2025 season."