The San Francisco 49ers looked out of their element as the Buffalo Bills cruised to an easy 35-10 win on Sunday Night ...

See what Kyle Shanahan, Brock Purdy, Sean McDermott and Josh Allen had to say following the Week 13 primetime contest.

The 49ers just lost their second game in a row by at least 25 points for the first time since Jim Tomsula was the head coach.

San Francisco 49ers head coach Kyle Shanahan revealed after Sunday night's loss to the Buffalo Bills that running back ...

Bills quarterback Josh Allen's fiancée, Hailee Steinfeld, is spotted for the first time since the couple announcement their ...

While the Detroit Lions didn't play Sunday, they did remain atop the NFC standings and still share the best record in the ...

49ers left tackle Trent Williams and his wife are mourning the death of their son last month. Sondra Williams announced in an ...

The Chiefs were the first team to clinch an NFL playoff berth, but the Bills can one-up them by sealing the AFC East with a ...

San Francisco has dropped three straight, including meek losses to the Packers and Bills by a combined 53 points, to drop to ...

Allen had a signature moment in the snow against the 49ers, but there promise to be plenty of twists and turns still ahead.

The Houston Texans defeated the Jacksonville Jaguars, 23-20, on Sunday afternoon, but the game itself was far from the top ...

Green Bay Packers Head Coach Matt LaFleur spoke with the media ahead of the team's trip to Detroit to take on the Lions.