The San Francisco 49ers improved to 8-4 on Monday Night Football, but reaching the postseason will still prove to be tough.

ESPN’s Dan Orlovsky says he’d be “shocked” if the NFC Super Bowl team isn’t the Rams, Seahawks or Eagles, leaving the 49ers out of his contender tier.

The NFL announced Tuesday that it suspended Carolina Panthers defensive back Tre'Von Moehrig for one game for striking San Francisco 49ers' Jauan Jennings in the groin area.

Brock Purdy's return was meant to boost the San Francisco 49ers' offense, but his second game back saw a different story.

Christian McCaffrey maintained that playing Carolina for the first time since the Panthers traded him to San Francisco three ...

San Francisco 49ers head coach Kyle Shanahan gives remarks following the Week 12 matchup vs. the Carolina Panthers.

San Francisco 49ers quarterback Brock Purdy spoke after the win over the Carolina Panthers about his three interceptions.

The loss left the Panthers a half-game behind Tampa Bay (6-5) in the division with their next game against arguably the best ...

The San Francisco 49ers earned a 20-9 victory over the Carolina Panthers in Monday's NFC showdown, but wide receiver Jauan ...

Brock Purdy threw for one touchdown and Christian McCaffrey ran for another to lift San Francisco over the Carolina Panthers 20-9 on Monday, boosting the 49ers' NFL playoff hopes.San Francisco ...

Carolina Panthers cornerback Jaycee Horn jumps the route and intercepts San Francisco 49ers quarterback Brock Purdy for the second time tonight.