RNA-guided CRISPR system activates gene expression

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally ...
IEEE

Protein-Binding RNA Prediction Based on Integrated Sequence-Structure-Function Pre-Training

Abstract: RNA binding proteins (RBPs) play a crucial role in regulating biological functions through their interactions with specific RNAs, significantly impacting various life processes.
Ars Technica

Tiny, 45 base long RNA can make copies of itself

There are plenty of unanswered questions about the origin of life on Earth. But the research community has largely reached consensus that one of the key steps was the emergence of an RNA molecule that ...
Phys.org

Could the discovery of a tiny RNA molecule explain the origins of life?

One of the greatest mysteries of our planet is how a soup of lifeless chemicals transformed into the first living cell. There are several competing theories about where this happened, from frozen ...
ZME Science

The “Quite Tiny” RNA Molecule That Could Answer the Question of the Origin of Life

Previously discovered large RNA polymerase ribozyme structure (grey, based on pdb: 8T2P) vs. newly discovered small RNA polymerase ribozyme QT45 (blue, AlphaFold3 prediction). Credit: MRC Laboratory ...
Nasdaq

Wave Life Sciences Announces Positive Interim Data from Phase 1 INLIGHT Trial of WVE-007 (INHBE) for Obesity; Single Dose Resulted in Improvement in Body Composition With Fat ...

Following a single subcutaneous 240 mg dose, WVE-007 (INHBE GalNAc-siRNA) improved body composition at three months compared to baseline, with a 9.4% reduction in visceral fat (p=0.02), a 4.5% ...
Scientific American

How RNA Unseated DNA as the Most Important Molecule in Your Body

We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...
gut.bmj

Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a 5-year survival rate of 12%. It has two major molecular subtypes: classical and basal, regulated by the master ...
GEN

Nipah Virus Polymerase Complex Structure Solved

Nipah virus is a zoonotic virus harbored by fruit bats. It can be transmitted to pigs and humans, infect people through contaminated food, and can travel directly from person to person via droplets.