Can the Niners turn 2024 into a repeat of 2020 — a one-year, injury-filled blip? The next seven months will decide.

San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the first offensive drive. The ...

The Arizona Cardinals and San Francisco 49ers entered the season final both struggling, Arizona having lost five of six and ...

The San Francisco 49ers are playing their final game of this brutal 2024 season and it's ending in largely the same way as it ...

Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the ...

The Bucs won their fourth straight NFC South title, while the Patriots' victory cost them the No. 1 pick. Here are winners and losers from Week 18.

The 49ers injury woes continue at running back after Isaac Guerendo was carted off the field in the 1st quarter.

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers’ season finale versus the Arizona ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

The San Francisco 49ers entered Sunday's season finale against the Arizona Cardinals with a depleted roster. Quarterback Josh Dobbs took the reins in place ...