See what Kyle Shanahan, Brock Purdy, Sean McDermott and Josh Allen had to say following the Week 13 primetime contest.

The 49ers just lost their second game in a row by at least 25 points for the first time since Jim Tomsula was the head coach.

The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on ...

The San Francisco 49ers suffered another disappointing loss on Sunday night as they took on the Buffalo Bills on the road in ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Christian McCaffrey’s injury threatens to sideline the 49ers’ star running back for the rest of the season. The team’s ...

The San Francisco 49ers' visit to Buffalo could be more painful than expected for Kyle Shanahan following the loss to the ...

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

This has led to a profound resource drain to the 49ers. They kept up their turn-and-burn roster approach of letting guys ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Christian McCaffrey's 2024/25 NFL season could be over in a devastating blow to the San Francisco 49ers after the 28-year-old ...

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.