The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their ...

Former NFL wideout Ed McCaffrey said it was a tough night after his son, 49ers running back Christian McCaffrey suffered a ...

See what Kyle Shanahan, Brock Purdy, Sean McDermott and Josh Allen had to say following the Week 13 primetime contest.

Rather than viewing this team as one of the class organizations of the NFC, we now need to ponder whether injuries, age, and ...

The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Christian McCaffrey’s injury threatens to sideline the 49ers’ star running back for the rest of the season. The team’s ...

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

Buffalo was a perfect 4-for-4 in the red zone. A big factor in the Bills' success was their run game. RB James Cook had 14 ...

The San Francisco 49ers’ Sunday Night Football showdown with the Buffalo Bills turned into a nightmare, and fans are not holding back. A 35-10 drubbing left the 49ers reeling and X ablaze with calls ...