Bosa is officially active against the Rams, via Ian Rapoport of the NFL Network. Joining him are running back Isaac Guerendo and Dre Greenlaw. While injuries have dismantled San Francisco throughout the season, all three returns will be massive for their hopes against Los Angeles.

As expected, the team has activated linebacker Dre Greenlaw from the physically unable to perform list. Greenlaw has not played in a game since tearing his Achilles in the Super Bowl in February, so it has been a long wait for him to be back in the middle of the action.