San Francisco isn't a stranger to taking chances on former starters. The 49ers had Sam Darnold on the roster last year and he ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The San Francisco 49ers are reportedly hoping that quarterback Brock Purdy's shoulder injury isn't a long-term issue, but ...

The San Francisco 49ers have reportedly emerged as a strong candidate to sign free-agent quarterback Daniel Jones. According ...

Former Buffalo Bills (and current San Francisco 49ers) defender Leonard Floyd will be facing off against his old club this ...

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...

Quarterback Tua Tagovailoa hopes to continue his hot streak in the cold when he and the Miami Dolphins visit Lambeau Field ...

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

But with the Detroit Lions at 10-1 and the Minnesota Vikings at 9-2, Green Bay is in third place in the NFC North. The ...