Even though the 49ers lost, George Kittle was the one to get the offensive spark going. The Rams got up 14-0, and the 49ers had run just three plays. After a first down play went for a loss, Kittle made a diving grab to move the chains, get the crowd into it, and show the fans that he was back.

NFL Week 11 odds, picks, predictions, TV channel, streaming information for Sunday football game between San Francisco 49ers and Arizona Cardinals.

Here's everything you need to know when the San Francisco 49ersplay the Arizona Cardinals Week 11 of the 2025 NFL season.

The San Francisco 49ers had a rough outing in Week 10, falling to the Los Angeles Rams 42-26. That put San Francisco at a 6-4 record, dropping them to third place in the NFC West, and outside of the playoff picture as a whole.

The San Francisco 49ers have a very unexpected quarterback controversy brewing in the Bay, as Mac Jones has filled in more than admirably while Brock Purdy has been sidelined with a toe injury.

The 49ers have had about enough when it came to rookie Connor Colby. He played from Week 3 through Week 8, but the team tried to substitute Nick Zakelj in for Colby during Weeks 7 and 8, and they finally replaced him with Spencer Burford in Week 9.

The Cardinals will be without star WR Marvin Harrison Jr. vs. the 49ers, a key loss as San Francisco looks to gain ground in the NFC West race.

As the 49ers approach the stretch run, it is the latter trait that is perhaps most appealing. While McCaffrey doesn’t lack physicality, it is obvious that is one area in which Robinson has the edge over the 49ers’ starter, and the numbers bear that out.